CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia
نویسندگان
چکیده
منابع مشابه
Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.
Chromosomal rearrangements involving the H3K4 methyltransferase mixed-lineage leukemia (MLL) trigger aberrant gene expression in hematopoietic progenitors and give rise to an aggressive subtype of acute myeloid leukemia (AML). Insights into MLL fusion-mediated leukemogenesis have not yet translated into better therapies because MLL is difficult to target directly, and the identity of the genes ...
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Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany; German Consortium for Translational Cancer Research, Heidelberg, Germany; Department of Internal Medicine III, Ulm University, Ulm, Germany; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; Department of Haematology, Cambridge Institute of Med...
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Translocation of the mixed-lineage leukemia (MLL) gene with AF4, AF9, or ENL results in acute leukemia with both lymphoid and myeloid involvement. We characterized leukemia-initiating cells (LICs) in primary infant MLL-rearranged leukemia using a xenotransplantation model. In MLL-AF4 patients, CD34(+)CD38(+)CD19(+) and CD34(-)CD19(+) cells initiated leukemia, and in MLL-AF9 patients, CD34(-)CD1...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2015
ISSN: 1934-5909
DOI: 10.1016/j.stem.2015.08.008